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Epinephrine, in particular, is known for its disadvantageous effect on splanchnic perfusion in septic patients [ 18, 19].
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In addition, the value of atenolol versus other beta-blockers in hypertension has been questioned, given its low lipophilicity, disadvantageous effect on central aortic blood pressure 41 and tendency to increase insulin resistance (potentially exacerbated in ASCOT by concurrent thiazide use).
However, as father's ISEI score steadily improves, this disadvantageous effect gradually disappears.
The disadvantageous effect of concentration polarization on the transportation of salt ions in interstitial solution is thus lessened.
Another possibility is that frequent headache attacks might have a disadvantageous effect on neurons at the dorsal pons, leading to neuronal dysfunction or atrophy in patients with CM.
The disadvantageous effect of this load position is not so severe when the load is taken by two parallel beams that are connected by an element.
In 2007 Dr Ian Walker, an expert in transport and traffic at the University of Bath, published research that demonstrated how helmets can have a disadvantageous effect on motorist behaviour.
The disadvantageous effect of high drift tolerance on arrival probability can also be seen in trajectories of modeled individual migrants.
Alpha-tocopherol has been reported to reduce γ-tocopherol concentrations in blood plasma [ 21] which could have a disadvantageous effect.
This disadvantageous effect on cell growth was strikingly augmented by the treatment with the DNA-damaging agent doxorubicin.
A disadvantageous effect of polyploidy is the possible disturbance of meiosis by doubled chromosomes which may prevent correct bivalent formation [ 7].
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