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Because of its dermal component and tendency to relapse, melasma is often difficult to treat.
Its dermal compartment consists either of adipose tissue-derived stromal cells, dermal fibroblasts (Fbs), or a mixture of both cell types.
However, due to its poor solubility, quercetin has limited skin penetration ability, and various formulation approaches were taken to increase its dermal penetration.
Its dermal denticles are also unusual, resembling the scales of a bony fish.
The most recognizable features of Stegosaurus are its dermal plates, which consisted of 17 separate flat plates.
Its lack of size is partly made up for by its strong body armour, provided by the bony bases to its dermal scales, which provides protection against predators.
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Type I collagen is among the most abundant ECM proteins and its excessive dermal deposition is one of the key features of systemic sclerosis (SSc) (scleroderma), a prototypic fibrotic condition [ 1- 3].
The ability of GHK to reset the genome to a healthier gene pattern which leads to a better regulation of various cellular pathways can explain its diverse dermal repair actions.
Improved drug deposition from liposomal preparations demonstrates its potential for dermal delivery.
Because fibulin-5 expression is induced dramatically in endothelial and smooth muscle cells in response to mechanical injury, my colleagues and I studied its role in dermal wound healing.
Findings about its role in dermal wound healing are controversial.
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