One possible explanation for how cytoplasmic PSA can rescue phenotypes mediated by supposedly extracellular Aβ is that a highly toxic subpopulation of Aβ migrates into the cytoplasm where it exerts its deleterious effects.
An important example is the toxin of Shigella dysenteriae, which has been shown to travel from the cell surface across endosomes, and the Golgi apparatus en route to the endoplasmic reticulum, and the cytosol, where it exerts its deleterious effects.
A slim majority of Justices is fashioning their demand for color blindness into a new totem and insisting on deference to it no matter what its deleterious effects upon the very groups that the equal protection clause was created principally to benefit.
Most cultures have taboos against close inbreeding (Brown 1991) and most nonhuman animals appear to avoid it, ostensibly as an adaptation to prevent its deleterious effects (Pusey and Wolf 1996).
Moreover, the inverse relationship between juice consumption and blood Pb indicates that frequent consumption of juices could be an effective way of keeping the blood Pb levels low, thereby avoiding its deleterious effects.
The editors of n+1 trace the mainstreaming of sociological terminology, and its deleterious effects.
Almost without exception, the effort to control this noxious industry and its deleterious effects is being fought town by town, county by county.
In this way, the alleles for late-onset Huntington's may evade natural selection, "sneaking" into the next generation, despite its deleterious effects.
Should we start by mourning the merciless passage of time and its deleterious effects on the indie upstarts who made Swingers 15 years ago, and let their minds and bodies go utterly to seed thereafter?
A prevalence of around 31% in France and its deleterious effects on the quality of life make allergic rhinitis a real health problem.
Alcohol consumption is a potential trigger for flare in inflammatory bowel disease (IBD) flare because of alcohol's pro-oxidant effects and its deleterious effects on gut barrier function.
