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Very recently nitric oxide (NO) was considered a highly toxic gas until its crucial function in humans was discovered.
GPC is an appealing immunogen because of the surface exposure of GPC in LASV virions and its crucial function for viral entry16,23,24,25,26.
Considering its crucial function in regulating various processes, ranging from metabolic detoxification to DNA repair, this transcription factor will be of high interest for future research.
Due to its crucial function, complete loss of EXOSC3 is likely to be lethal.
Analysis of the new vac14 and fab1 mutants provides insights into the organization of the PI 3,5 P2 regulatory complex and its crucial function in the mammalian nervous system.
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Protein "quality control" might have been the original role of the ubiquitin system and remains one of its crucial functions to this day [ 83- 85], even as it evolved to assume many other roles.
Thus, the occlusion of V3 in the HIV-2 envelope complex may prevent it from over immune recognition and associated sequence changes thereby preserving its crucial functions in viral entry.
This much came into crisp focus when public editor Arthur Brisbane asked his readers, "Should The Times Be a Truth Vigilante?" I quit working in mainstream news12 years ago, but I still consider myself a journalist, and still care very much about the profession and its crucial role in the functioning of a healthy democracy.
Given its crucial role in maintaining mitochondrial function, DJ-1 represents a potential target for novel therapies for other pathologies involving mitochondrial dysfunction and cell death, including IRI.
But its crucial secondary function was to ask students to reconceptualize their own role as creators and perpetrators of historical narrative.
Taken together, our data shows that while MOF is the major acetyltransferase for lysine 16 of histone 4 (Taipale et al., 2005), MSL-dependent H4K16 acetylation is one of several means through which MOF exerts its crucial biological functions.
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