We reasoned that if R224 is genuinely a pHo sensor and by itself is capable of interfering with K+ permeability in its charged form, it should be possible to transfer this ability by transplantation into a channel that does not possess a charged residue at the equivalent position.
A triplatinum compound of the series (BBR 3464) was selected for preclinical development, since, in spite of its charged nature, it was very potent as cytotoxic agent and effective against cisplatin-resistant tumour cells.
Anthony DeCurtis of Rolling Stone wrote in his four-star review that the album was "a daring, imaginative coda to Achtung Baby" and that "it is varied and vigorously experimental, but its charged mood of giddy anarchy suffused with barely suppressed dread provides a compelling, unifying thread".
6.30pm BST 27 min: Eriksen resorts to a long shot but its charged down by Metoua.
With its short and evocative chapters, its charged and playful language, its movement to and fro in time, the novel is indeed poetic.
By aiming for documentary-style realism, United 93 has largely avoided the political storms that might have resulted from its charged subject matter.
