This paper presents a body of program synthesis knowledge dealing with array operations, space reutilization, the divide and conquer paradigm, conversion from recursive paradigms to iterative paradigms, and ordered set enumerations.
They also revolutionized the coding theory by establishing a new soft-iterative paradigm, where long powerful codes are constructed from short simple codes and decoded through iterative message exchange and successive refinement between component decoders.
We propose the adoption of an iterative design build test learn paradigm to improve PKS engineering.
By shifting away from the conventional iterative fit-and-refine paradigm, we present a novel split-connect-fit algorithm to more efficiently perform the T-spline fitting.
Our structure further demonstrates the remarkable plasticity of the substrate binding cleft of the BoNT/A LC protease and provides a paradigm for iterative structure-based design and development of BoNT/A LC inhibitors.
This fitting process is optimally solved by a hybrid optimization technique coupling a random sample consensus (RANSAC) paradigm and an iterative closest point (ICP) matching procedure.
In fact, the multiple carrier turbo Volterra equalizer [4] relies on the powerful, but highly complex, iterative interference cancellation and decoding paradigm.
With the TrixX approach, we introduce a new paradigm avoiding the iterative process of virtual screening while yielding comparable re-docking results and enrichment rates.
From these studies, in conjunction with the wealth of information recently obtained regarding the evolutionary pathways and paratopes/epitopes of multiple bnAbs, it has become clear that the very features of bnAbs desired for their function will be problematic to elicit by traditional vaccine paradigms, necessitating more iterative testing of new vaccine concepts.
These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design.
