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HMT activity of MMSET is essential for its oncogenic function, so it would seem straightforward to design small molecular inhibitors to target MMSET substrate binding pocket.
It would seem straightforward to test this model by assessing the frequency of MT binding events or an assay similar to that used in Figure 1.
In principle, it would seem straightforward to evaluate if the alterations in energy metabolism induced by these neurotoxins are dependent on ROS formation by overexpression of antioxidant enzymes or exposure to antioxidants.
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Its history would seem straightforward: brilliant inventor makes a breakthrough, cleverly stands conventional organisational principles on their head and, presto, the world is a better place.
Defining elder abuse would seem straightforward, but it's not.
On its face, a NEPA review would seem straightforward.
Therefore, it would seem reasonably straightforward that further research on the additive and interactive effects of respondent status in longitudinal studies of treatment efficacy and effectiveness that rely on patient-reported outcomes is warranted.
It would seem that a straightforward way to ensure that successive recordings reflect activity of the same neuron is to show that the spike waveform is constant across recording sessions.
It would seem to be a straightforward expectation that larger genomes would contain both more types of TEs and more copies thereof than smaller genomes.
But in the quantum Universe, this notion of relativistic causality isn't as straightforward or universal as it would seem.
Even when an in vivo phenotype and a biochemical function are known, it would seem that linking the two is not necessarily straightforward.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com