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In the light of these facts it was logical to hypothesize, that leukopenia would be a possible cause for the observed synergistic action of IAV and S. pneumoniae, more so, as TLR7 would provide a valuable mechanistic link.
Because fibrosis features are similar between patients with alcoholic liver disease and NAFLD, it was logical to hypothesize that the diagnostic value of FT would be the same.
Given the pro-tumorigenic cellular processes governed by β1-integrin signalling and given the effect of JAM-A expression on β1-integrin protein expression, it was logical to hypothesize that JAM-A may directly regulate downstream β1-integrin-mediated processes.
As ALL cells, similar to tumor cells of other origin, have increased glucose uptake and glucose dependence, it was logical to hypothesize that inhibition of glucose uptake would lead to cell death.
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It is logical to hypothesize that these environmental compounds are capable of changing estrogen metabolism, leading to increased formation of catechol estrogen quinones.
It is logical to hypothesize that the negative regulator of PI3 kinase, PTEN, should also be necessary for regulating gastrulation cell movements in zebrafish, but no gastrulation defects was observed in zebrafish pten mutants [37].
Thus, it is logical to hypothesize that PR is unnecessary or PR happens soon in generalized food-deceptive orchids in the promotion of cross-pollination.
It is logical to hypothesize that FAE might alter DNA methylation, thus suppressing the transcriptional machinery involving a variety of transcription factors.
Being able to discriminate tumour origins, subtypes, oncogenic mutations and cancer predisposition, and regulating the most important cellular processes, it is logical to hypothesize that miRNAs might be able to predict also cancer prognosis and/or response to specific therapies.
Therefore, it is logical to hypothesize that this organism has an arsenal of accessory virulence factors, which aid in host colonization, help gain a competitive advantage to act synergistically and modulate host gene expression.
It is logical to hypothesize that the antioxidant role of UA might be more relevant in older subjects than in younger subjects because the skeletal muscles in elderly persons have reduced overall antioxidant capacity to counteract ROS [ 32].
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