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As our study subjects were nearly two decades older and had a condition (heart failure) that has a poor prognosis and usually necessitates treatment with multiple drugs, it is not unreasonable to speculate that clinicians may have been reluctant to contribute further to the polypharmacy in these patients by adding glucose-lowering agents.
A clam is a bad note that comes up during the making of a record, which usually necessitates a retake.
Regeneration of bone defects is a clinical challenge that usually necessitates bone grafting materials.
The resultant cranio-atlanto-axial instability usually necessitates subsequent posterior stabilization.
(1) The presence of biofilm on an infected prosthetic usually necessitates surgical replacement as a curative treatment due to an increased resistance of these bacteria to antibiotics.
For babies and young toddlers with poor cooperation with dentists and severe dental caries in their oral cavities, treatment of ECC usually necessitates the use of general anesthesia.
This approach usually necessitates the use of polypharmacy with an attendant increase in costs and the risk of adverse events.
A major spleen rupture usually necessitates splenectomy.
Venous-graft thrombosis may result in pancreatic necrosis or duodenal stump breakdown, which usually necessitates graft pancreatectomy.
Chemical exfoliation usually necessitates intercalating various small species (i.e., organic molecules, alkali metals and transition-metal halides) into the interlayer spaces to achieve the exfoliation.
Complete removal of a HCC-RA thrombus usually necessitates a total hepatic vascular exclusion technique [4] or cardiopulmonary bypass [5, 6].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com