During megakaryocyte maturation, the polyploid cell undergoes a complex process of cytoskeletal rearrangement, followed by proplatelet elongation, and the release of cytoplasmic fragments as circulating platelets [27].
They undergo a complex process of morphological and physiological differentiation that leads to the production of exospores and specialised metabolites [ 1] with a wide range of biological activities.
The thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation.
The thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation, eventually leading to the migration of positively selected thymocytes to the T-dependent areas of peripheral lymphoid organs.
They are Gram-positive mycelial soil bacteria containing about 70% G-C DNA content and undergo a complex process of morphological development that usually involves secondary metabolite biosynthesis under depleted nutrient conditions [ 6].
Among the newer antiplatelet agents, prasugrel is also a prodrug but it undergoes a less complex activation process that is not believed to involve CYP1A2; ticagrelor is itself an active moiety whose metabolism only slightly involves CPY1A2.
The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides.
Post-printing and before implantation, the 3D biological structure undergoes a complex maturation process governed by both biological and physical mechanisms.
However, at this point we only have a candidate drug, which then undergoes a complex evaluation process referred to as drug development.
SP-B is a relatively small (79 amino acids) hydrophobic polypeptide that is synthesized as a longer, 381-amino-acid precursor that undergoes a complex maturation process along the exocytic pathway of type II pneumocytes [ 8].
In its use as bone substitute material, it undergoes a remodelling process and transforms to bone.
