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Whether of known-cause or idiopathic, PF is a challenging disease for patients to live with: it typically progresses and shortens survival; its symptoms shortness of breath, nagging cough and fatigue limit physical and social activities and impair patients' quality of life (QOL) [ 2, 3]; and there is no cure.
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Its clinical phases typically progresses over time from an early chronic phase (CP) through an accelerated phase (AP) and terminal blast crisis phase (BC).
It is preceded by microalbuminuria, which typically progresses to proteinuria and overt nephropathy when left untreated.
It is important to note that the disease course typically progresses over time, and although treatment would ideally result in improvement or stop progression, a positive intervention could still be obtained if disease progression occurred at a slower rate in treated patients than for control MS subjects.
The peritoneal thickening can be smooth or irregular and nodular, and mild peritoneal thickening typically progresses to diffuse, severe peritoneal thickening and eventually peritoneal calcification.
Due to the high capital cost coupled with long lead time, a pipeline project typically progresses through a series of phases.
The disorder typically progresses until the third to fourth decade of life [3], and the factors that determine the progression or stabilization of the disease are not well characterized or understood.
This subluxation typically progresses after posteromedial release.
The subluxation typically progresses after posteromedial release.
OA is a degenerative disease and typically progresses more slowly.
KC typically progresses until the third to fourth decade of life [ 2].
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