Builders and developers hated the Bates Law, calling it too stringent and an assault on property rights.
The workflows may also be repurposed to suit other objectives, for example, to filter out non-specific connections, we remove hub metabolites like ATP, NADP and other entities like co-enzymes; however, users may change the filtration criteria if they find it too stringent for their objectives.
Based on the study of Newey et al. [16] as well as based on experience from extensive use of SISCOM in clinical routine, we chose not to evaluate a z-score threshold of neither 1 SD, because it shows too much propagated activity, nor 2.5 SD because it is too stringent and only shows clusters of very intense relative hyperperfusion.
That solution has now been rejected by Theresa May, not because it is too stringent but because the model is too lax, with too many avenues for automatic entry entitlement.
While critics often accuse the F.D.A. of letting unsafe drugs on the market, this case points to pressure on the agency from the opposite direction — patients who say it is too stringent in approving drugs for serious diseases.
However when the criterion was increased to 2.5, it became too stringent and many gene clusters were no longer recoverable from the component growth stage.
Although the authors found highly endothelial specific genes applying this q-value, in this work it was considered too stringent as endothelial genes expressed at a low level could be missed because of low coverage sequencing of cDNA libraries.
It might be too stringent to demand the conservation of the whole hairpin in miRNA identification studies [ 35].
Although Bonferroni correction is commonly used, it can be too stringent and results in type II errors, and hence the sequential goodness-of-fit (SGoF) method (Carvajal-Rodríguez et al. 2009), which is particularly suited to high-dimensional data, was used to correct for multiple testing for all genetic data.
The aide, who declined to detail what has been discussed so far, cautioned that if the pay-for were too stringent, it could drive some progressive Democrats to abandon their support for the bill.
However, this parameter was not applied as a cut off criterion since it would have been too stringent for some comparisons, resulting in no significantly regulated genes at all.
