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The pathways shown in Figure 6 are likely highly interconnecting, and this model, and the individual functional interactions it suggests, need to be validated (and probably significantly extended) by direct experimental targeting of microRNA levels and measurements of each of the predicted target genes in a larger cohort (such as is planned for The Cancer Genome Atlas (TCGA) in its next phase).
It suggests need for new innovations including incorporation of HMIS in the ongoing reviews of the curricula for all cadres of health care providers, development of more user-friendly system and use of evidence-based John Kotter's eight-step process for implementing successful changes in this system.
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Attack suggests need for new data safeguards.
This situation emphasises the need for authors to consult Instructions to Authors before submission, but even more importantly, it suggests the need for at least national, if not international, policies in all fields of medical research.
Indeed, it suggests a need to examine, on many levels, the intersection of the health and criminal-justice systems.
That is no reason to abandon these studies, but it suggests the need for deep thought on how best to design them and implement the findings.
It suggests we need to rethink working requirements for the ageing population, who are being expected to work longer and care for more grandchildren.
For example, it suggests the need to tackle a specific area of legislation known as controlled foreign company (CFC) rules is not a priority.
There is plenty of blame to go around in the Sutton case, legal experts said, and it suggests a need for an independent investigation and systemic reform.
It suggests the need for outreach and interaction between scientists and local people prior to and during a volcanic eruption.
It suggests the need for viewing nature as a deeply organic and connected system of relationships that is not necessarily or readily submissive to reductive thinking and analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com