The phrase "it substantially affects" is correct and can be used in written English.
It is often used to describe something that has a significant impact or influence on something or someone else. Example: The new tax laws will substantially affect small businesses in the country.
It substantially affects the nature of the social security system without reforming any of the criteria that are considered to be the most important ones, such as the contribution rate, retirement age, contribution bases, pension formulae, etc.
Their collective view is that, whatever you think of the policy behind the law, it's clearly constitutional based on existing precedent because it substantially affects commerce under the Commerce and "Necessary and Proper" Clauses of the Constitution.
Therefore, it substantially affects the quality of life.
The resources need not be all monetary or monetary equivalent; information, for example, is a hard to quantify resource, yet it substantially affects the outcomes of the system.
It is not a life threating condition and death rate is almost nonexistent but it substantially affects the quality of life.
Ventilation is particularly important because it substantially affects indoor air quality (Baumgartner et al. 2011; Johnson et al. 2011; Nazaroff 2008).
A nonlinear equilibrium tends to sharpen or spread concentration waves as in fixed-bed sorption; it also substantially affects the direction and velocity of wave propagation.
As with the growth of "organic unity" views in the context of debates about intrinsic value, it is becoming common to think that life as a whole (or at least long stretches of it) can substantially affect its meaning apart from the amount of meaning in its parts.
Although family involvement in ownership and management is important, it fully reflects the nature of family businesses only when it can substantially affect the company's objectives, strategies, and organizational structures (Chua et al. 1999).
This type of mechanism depends on the geometrical and mechanical features of the structure, but it is substantially affected by the constraints along the structural frame.
The damage increased with the number of cycles, it is substantially affected by the fired clay porosity and calcium content, being consistent with the thermodynamics and kinetics of the mechanisms that lead to failure.
