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From a hemodynamic point of view, it might be argued that, in volume-resuscitated patients, norepinephrine may potentially be advantageous over phenylephrine, since it simultaneously stimulates α1, β1 and β2 receptors, thereby counteracting arterial hypotension by increasing systemic vascular resistance and possibly myocardial inotropy [ 6].
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Thus, it appears that HIF simultaneously stimulates the polycythaemic response to hypoxia and boosts the availability of iron so as to meet the resultant erythropoietic demands.
In the short term, it induces symptoms such as heat, pain and swelling, but this kills dangerous microbes and simultaneously stimulates bodily repair and regeneration.
This book relaxes and simultaneously stimulates me.
The male crawls over the female and regularly taps his chin on her back; this behaviour presumably results in an exchange of pheromones, which simultaneously stimulates the participants.
Mental masturbation often simultaneously stimulates my sub-abdominal muscles to the point where by the time I've figured out the right algorithm to apply to a recursive function, I find myself unwittingly dry humping my desk.
I may not agree with all of its conclusions, but there are few things I love more than a well told story that entertains and simultaneously stimulates deep reflection and introspection.
Starvation also inactivates TORC1 signaling, which probably simultaneously stimulates autophagy as well as starvation-induced endocytosis.
For example, TNF receptor mediated signaling simultaneously stimulates pathways for apoptosis induction via caspases and pathways for suppression of apoptosis via nuclear factor (NF -κB [ 109, 150, 154].
Thus, the increase in MYC levels resulting from miR-92a expression simultaneously stimulates proliferation and engages the p53 tumour suppressor pathway, resulting in apoptosis.
TGF β has also been shown to activate the recruitment of VEGF-expressing hematopoietic effector cells, establishing a potent signaling network in the inflammatory wound environment that simultaneously stimulates neovascularization [ 114].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com