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NPM1 loss may have occurred as an early step in MDS/AML as it remained stably mono-allelic in 4 NPM1+/− patients and did not develop in 6 NPM1+/+ over a median of 9 months follow-up (range: 2 156 months) (Table 2).
A significant difference was found, meaning that proximity seeking to the ITAB therapist increased during periods of heightened arousal, whereas it remained stably low for the control therapist.
Whereas Stl1-GFP was internalized within 5 min after glucose addition in WT cells, it remained stably associated to the plasma membrane in the rod1Δ mutant and was not internalized even 30 min after glucose treatment.
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However, it remains unclear why ATF4 remained stably upregulated even though the level of eIF2α phosphorylation was only transiently activated.
Any tendency towards rearrangement by these genes is no longer apparent, as each gene partner has remained stably associated with its RecQ paralog for more than 80 million years.
We therefore reasoned that it might be possible to use mRNA-display to evolve a population of ATP binding proteins that remained stably folded in the absence of excess ligand if such variants existed and if our starting library contained enough sequence diversity to examine a significant region of sequence space around the ATP binding domain.
Urban policy analyst Ingrid Gould Ellen has documented steady growth in both city and suburban neighbourhoods that have remained stably integrated over time.
The results showed that the implanted TSC sheet remained stably attached on the tendon surface at 4 weeks after implantation.
Dispersion experiments confirmed the nanotube surface modification of the nanotubes since functionalized MWCNTs remained stably dispersed in an ethanol/xylene solution for more than 48 h after sonication.
Liposomes targeted with CRPPR or other arginine-rich peptides with an exposed guanidine moiety bound within 100 s after intravenous injection and remained stably bound.
However, when anti-CD117 antibody treatment was used in combination with transplants of normal human blood stem cells, normal human blood formation was restored and high-risk MDS cells remained stably suppressed throughout the course of the experiment.
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