The small number of suitable companies listed on the market, and the high return volatility of individual equities make it difficult to reliably achieve superior returns.
54, 55, 56 High between‐subject variability in busulfan pharmacokinetics makes it challenging to reliably achieve this target with the FDA‐approved dose of 1.1 mg/kg for children ≤12 kg and 0.8 mg/kg for children >12 kg.
TOF PET was extensively studied in the 1980s but died away in the 1990s, as it was impossible to reliably achieve sufficient timing resolution without sacrificing other important PET performance aspects, such as spatial resolution and efficiency.
The extremely high level of Pea3 expression in MMTV/Wnt1 mammary tumors rendered it technically challenging to reliably achieve X-gal staining of tumor samples, due to rapid precipitation of reaction product on the tissue surface.
However, the biochemical parameters that describe TF promoter interactions are often context dependent, making it challenging to build systems that reliably achieve specific outcomes.
From the days of Alexander Hamilton to the 1960s it was an article of faith that the dollar should be strong and stable; this could be reliably achieved only by anchoring it to gold.
In any case, from the engineering point of view the surface state of an adherent in a bonding process or a substrate in a coating process may be most reliably achieved if its change after the grinding is minimal.
Competition should generally be the default option for achieving affordability, as it has proven superior to tiered pricing for reliably achieving the lowest sustainable prices.
It is representative of an adaptive challenge -- we're all working on it, but no one has figured out how to reliably achieve this outcome for all students.
In considering the ongoing process of validation once the instrument has been developed, it is necessary to specify the interpretations and applications that we are seeking to validly and reliably achieve.
We conclude that regulating or taxing observable emissions would more reliably achieve emission reduction.
