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Despite the fact that the fortress' renovations and new construction had not been finished, it presented a formidable challenge to its attackers.
The heterogeneity of immunosuppressive mechanisms in EOC presents a formidable challenge for immunotherapy, as it suggests that multiple immunosuppressive mechanisms might need to be reversed to restore T-cell function.
The immensity of T cell diversity presents a formidable challenge to its study and the aforementioned techniques lack sufficient depth of coverage (ability to detect low-frequency clones) and resolution (lack of sequence information without additional cloning steps).
This research presents a formidable challenge.
This presents a formidable challenge for urban planners and managers.
The enormous diversity of HIV-1 presents a formidable challenge for developing an effective AIDS vaccine.
Non-participation in landscape planning presents a formidable challenge to sustainable development.
The federal bureaucracy presents a formidable challenge for presidents with an aggressive deregulatory agenda like Trump's.
The sheer number of raters at diverse sites in multicenter trials presents a formidable challenge in calibration.
Microvascular reconstruction of the pediatric mandible, particularly when necessitated by severe, congenital hypoplasia, presents a formidable challenge.
Following some relief in Washington that Pyongyang's missile launch proved a failure, the threat to abandon the talks presents a formidable challenge to Obama.
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