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Prof Giovanna Mallucci told the BBC: "The novelty here is we're just targeting the protein shut-down, we're ignoring the prion protein and that's what makes it potentially relevant across the board".
Thirdly, the large overlap with RF positivity questions the value of determining ACPAs in the course of the disease, making it potentially relevant only for RF-negative patients or low-titre RF-positive patients, as previously suggested [ 4, 44].
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Immune traits (ITs) are potentially relevant criteria to characterize an individual's immune response.
It is potentially relevant that some conserved noncoding elements (CNEs) are repeated elements (Kamal et al. 2006) and CNEs are associated with various neural crest genes associated with known neurocristopathies (Amiel et al. 2010).
Although the reduction of finger skin blood flow was not related to subjective complaints in the present study, it is potentially relevant that some patients with musculoskeletal complaints report a cold feeling in wrist/hand [ 26, 27].
If any single author thought it to be potentially relevant, it was retrieved for further review.
It acts on potentially relevant substrates like mucin, fibronectin, lactoferrin and the A subunit of CT [8], [10].
As such, it represents a potentially relevant target for therapeutic intervention in many cancers and several inhibitors of STAT3 are currently under investigation [ 9, 10].
This may be especially pertinent in the case of the genealogically-linked surviving lineages of P. taeniata, P. hyalina and P. clara, but it is also potentially relevant for conservation measures involving Thaitian montane refuges where snails with robust phylogenetic ties to extirpated Moorean lineages still persist.
If an entry was identified by at least one of the reviewers as potentially relevant, it was included in the second stage of screening.
It is noteworthy and potentially relevant to the current study that, in neurons, VAMP7 is involved in axonal and dendritic outgrowth [ 45] and is associated with as yet unidentified vesicular structures present in axons and dendrites [ 44].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com