It poses considerable difficulties in surgical histopathology.
However, the way the knowledge is captured poses considerable difficulties for reuse.
In particular, assigning clinical meaning to each somatic and germ-line variant, including the therapeutic, prognostic, and diagnostic implications for individual patients, poses considerable difficulties in light of the inconsistent state of genome biological annotation.
From the point of view of in-service life, oxide formation poses considerable difficulties.
Experimental identification of disease-related microRNAs poses considerable difficulties.
There is a reflexive loop here that poses considerable difficulties to practitioners and patients alike, as attested by the centrality of the task of learning how to differentiate between 'real' physiological hunger and 'emotional' or 'triggered' hunger.
The validation of the concentration levels of indoor contaminants and the measurement of ventilation parameters with CFD simulation results often poses considerable difficulty due to the effect of several confounding factors.
Religious fundamentalism exists, of course, and it poses considerable societal problems, because it rejects values based on individual choice and personal freedom.
Cultivation of F. tularensis is often avoided, since it poses considerable risks of laboratory-acquired infections via aerosolization.
In doing so it has posed considerable challenges to how we assess and prevent harmful chemical exposures.
However, xenografting as a routine will pose considerable logistical difficulties as technical expertise of different fields (surgery, pathology, molecular biology and animal care) must be brought together.
