Separation of these two types of gene environment relationship has posed a major difficulty in quantitative genetic research.
For the time being, in most developed countries, an access to ABPM for a high-risk patient, such as one with diabetes, should no longer pose a major difficulty, also in relation to its reimbursement by health insurance bodies.
This poses a major difficulty for a reliable interpretation of geochemical results.
The choice of a suitable reference electrode for electrochemical testing of metals in organic solutions poses a major difficulty.
A 3D simulation of turbulent flow and coupled heat transfer between the working fluids poses a major difficulty because the range of length scales involved in heavy-duty radiators varies from few millimeters of the fin pitch and/or tube cross-section to several meters for the overall size of the radiator.
Still, lack of substantial fossil evidence of the development of the wing joints and muscles poses a major difficulty to the theory, as does the seemingly spontaneous development of articulation and venation, and it has been largely rejected by experts in the field.
Such requirements, Khanna stated, confer a heavy administrative and financial burden and consequently, pose a major difficulty for non-profit PDPs like Aeras.
As a result, many proteins show no or low sequence match to the known proteins in the database, posing a major difficulty in genome annotation.
It poses a major threat to the state of Israel".
Veracity or trustworthiness of data It poses a major challenge with regard to volume, variety, and velocity.
It poses a major public health threat to the developing and the developed world as an emerging infectious disease.
