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And, it often demands profound culture change.
A general limitation associated with conventional occupancy-driven target inhibition is that it often demands full target engagement, requiring sustained high concentration of a potent small molecule inhibitor over a prolonged time.
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(They were so different from, say history painting, which impressed by the sheer acreage of wall space it often demanded in order to tell its world-changing stories, and to show off its world-dominating statesmen).
In the past, it often demanded extensive references and other checks before someone would be admitted to training camps to prevent just such an outcome as occurred in this case.
Its paradigmatic expression is found in friendship, to which loyalty is integral, but many other relationships and associations seek to encourage it as an aspect of affiliation or membership: families expect it, organizations often demand it, and countries do what they can to foster it.
In a show that so often demands armor, it was a powerful reprieve: the chance to be more than just another hungry dog.
Programming directors decide what gets broadcast, but the propaganda ministry often demands changes.
Second, realize that the connection with aging parents often demands a reinvention.
And the cost of living in Westchester often demands that both parents in a family work.
This step often demands a considerable amount of material and human resources.
The matrix produced is banded and often demands substantially less memory resources.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com