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The following year, Halder et al. (1995a) manipulated the expression of the eyeless gene in flies so that it was active in tissues other than where it normally functions, with the result that eyes formed on the wings, the legs, and the antennae.
Our results are consistent with the notion that Rac1 nuclear accumulation serves to sequester this protein from the plasma membrane where it normally functions, potentially targeting it for degradation.
PTEN is commonly mutated in various cancers, as it normally functions as a tumor suppressor to antagonize the effects of PI3K through its lipid phosphatase activity.
This phosphorylation event excludes Yki from the nucleus, where it normally functions as a coactivator for the expression of Hippo pathway target genes.
As no specific ligand for ErbB2 has been identified so far, it is believed that it normally functions as a dimerization partner of the other ErbBs [ 9].
This mutation impairs CFTR folding, leading to the defective trafficking of this protein to the plasma membrane of secretory epithelial cells, where it normally functions as a chloride channel [ 3].
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Post-menopausal women also show increased DAT binding following E2 replacement therapy [ 233], which supports the idea that exogenous E2 can positively regulate DAT function in an E2-deprived condition, whereas it may normally function to suppress DAT function (and thereby increase DA neurotransmission) in the context of cycling hormone levels.
In turn, it suggests that α5 β1 normally functions to limit IL-8 secretion per cell, while at the same time increasing proliferation and therefore the number of secreting cells.
'It's an organ that normally functions well but, if put under too much strain, it starts not functioning properly.
Calcitonin normally functions to lower the concentration of calcium in the blood when it rises above the normal value.
The space, which normally functions as a club, welcomed the festival at the last minute after another venue cancelled.
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CEO of Professional Science Editing for Scientists @ prosciediting.com