The use of more than one primary outcome (co-primary outcomes) necessitates adjustments of the thresholds for significance because of problems with multiplicity [ 34].
A continued controversy exists whether the assessment of the influence of low birth weight on adult blood pressure necessitates adjustment for adult weight in the analysis on the fetal origins of adult diseases hypothesis.
AKI necessitates adjustment of dosage of renally eliminated drugs and avoidance of nephrotoxic drugs.
Still, the universities conceded that the Sept. 11 attacks had already necessitated adjustments.
Even in the presence of light, changes in physiological conditions frequently necessitate adjustments in the relative rates of reactions of the Calvin-Benson cycle, so that enzymes for some reactions change in their catalytic activity.
This was the first time a windblown-sand-prevention system was constructed in such a high-cold and arid environments; because of this, our work necessitated adjustments during the application of a number of different sand-damage prevention engineering techniquesand-damage prevention
Firewall configurations at Surrey and NGS necessitated adjustments to how the experiments might have been performed.
Conversely, changes in the broad scheme will often necessitate adjustments in the cognitive and probative schemes: changing social goals lead to revaluations of scientific knowledge and research methods.
Ensuring a strong recovery will necessitate adjustments across different parts of the global economy, while requiring macroeconomic policies that promote adequate and balanced global demand as well as decisive progress on structural reforms that foster private domestic demand, narrow the global development gap, and strengthen long-run growth potential.
The physiologic changes in pregnancy and the presence of a second, dependent, patient may necessitate adjustments to therapeutic and supportive strategies.
These concentrations are higher than previously recognized in chicken, which may necessitate adjustments to estimates of arsenic ingested through diet and may need to be considered when estimating overall exposure to arsenic.
