However, the findings from the current study might be validated with measures that are more adjusted to the teacher profession, such as teacher self-efficacy (Schwarzer et al. 1999).
This review first discusses aspects of the Cyc system, with a focus on important decisions made in designing its knowledge representation language, and on how claims about the performance of the system might be validated.‡ The review then turns to the book itself, discussing both its merits and its faults.
Still, small variations around the cut-off values should be treated with caution when deciding for LTBI therapy and new cut-offs might be validated.
In the revised manuscript we offer some hints on how the functional consequences from our model might be validated by mutating the acidic residues of Apaf-1.
For the other 126 analytes, the method still can provide semiquantitative information about the degree of contamination, and additional analytes might be validated afterwards, if needed.
The first proposed extension might be validated by data collection and epidemiological modeling of age-specific susceptibility and case fatality ratios.
Although this might be enough for SDRs that are validated as being "signals" upon first appearance, many true signals might be validated as "no signal" upon first appearance, but safety information coming in later might cross the "tipping point" where prior "no signals" turn into "signals" requiring verificatory actions.
34 The hope is that by providing randomised evidence of the effects of drugs in humans without requiring participants' exposure to a new molecule of uncertain safety and efficacy new drug targets might be validated and the risks of late stage failure in drug development reduced through the application of genetic studies during early drug development.
Since none of the ERCC1 antibodies usually used distinguish between functional and nonfunctional isoforms, it might be difficult to validate the correlation between the level of ERCC1 expression and OS on the basis of IHC detection; in effect, the expression of nonfunctional ERCC1 isoforms may lead to false ERCC1-positive cases and biased results.
Strong overexpression of both genes in PA I in comparison to higher grade astrocytomas suggests a potential contribution to the non-invasive growth behavior of PA I. Thus, it might be worth to validate this potential link by gene knockdowns in a future study.
