For that view implies, in Adams's words, that "the creator's choice of an inferior world must manifest a defect of character".
To determine whether mutants expressing a single VPg could also manifest a defect in cell entry, the capacity of mutants V19-4 and V3 expressing either wild type 2C or 2C with R55W to enter cells was determined.
DOCK2-deficient neutrophils manifest a severe defect in PIP3 formation and F-actin polymerization at the leading edge.
However, CS patients with IGT or diabetes manifest a baseline defect in β-cell secretory responsiveness that is partially retrievable along with improvement in insulin sensitivity (increase trend in disposition index) with mifepristone treatment.
Equally importantly, PTH-induced bone in Atf4−/− mice cannot mature due to a severe defect in osteoblast differentiation as manifested by a defect in Osx expression.
Cells from mice that lack the H2AX gene manifest a G2/M checkpoint defect similar to that in ATM-deficient cells exposed to low doses of ionizing radiation (12).
In Drosophila, the null phenotype manifests as a defect of axonal development, while knockout mice show impaired motor learning and cerebellar synaptic plasticity.
Persons with Down syndrome often manifest a variety of immune defects and several risk factors for adverse outcomes for pandemic (H1N1) 2009, including obesity, diabetes, and cardiovascular diseases.
Thus, SCN1B haploinsufficiency might have a synergistic effect with pimozide making manifest an otherwise hidden abnormal repolarization defect.
Biochemically, MELAS manifests as defects of complex I and IV activity; however, care must be taken when interpreting the findings as biochemical results can often appear normal.
The results described so far suggest that WASp−/− B cells manifest either a survival/homeostatic defect or a specific developmental defect(s) leading, ultimately, to severely reduced numbers of mature MZ, B1a, and recirculating naive B cells.
