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Here we show that peptide nucleic acid (PNA) is apt material for real-time PCR fluorescence probe for melting point analysis because it makes a large difference in the melting temperature (ΔTm) between full specific hybridization and that of single mismatch, including insertion and deletion.
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Where you park your car and how you shield it during parking makes a large difference to how hot it feels.
It represents a situation in which the Lagrangian optimization makes a large difference in the total utility of the system.
So my pain medication is NOT my primary source of pain relief, but it is the one thing I can take that immediately makes a large difference in my pain.
The stabilization makes a large difference in picture quality.
SIMD vectorization only makes a large difference in performance for low number of cores.
Oil droplet size distribution (CV) also makes a large difference, as shown in Figure 5B.
However, if the amount of water-oil interface area is relatively small and limits the biomass growth, the maximum microbial density makes a large difference (Figure 6A3).
In this study, considering RTM makes a large difference for the numbers of fatalities and seriously injured people, but for all injury accidents.
But who wins makes a large difference for the environment in which we're organizing".
A simple modification of the elution condition in the phage-display panning protocol makes a large difference in determining success.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com