"You'll spend less money over those first seven years if you've got a lower rate, but in terms of what the house will be worth," he said, "I'm not sure it makes a substantial difference".
Again, it makes a substantial difference whether such exchange reactions are included in the model or not.
From a clinical standpoint, having an FPG of 120 or 130 mg/dL or having a 2-h PG of 185 or 215 is virtually the same, but from the patient's perspective (perception of having a disease, psychological well-being, health insurance, recognition of particular benefits, or imposition of certain limitations, etc)., it makes a substantial difference.
It has made a substantial difference during these last 21 years that Anthony Kennedy got the seat intended for Robert Bork.
I think we had a moment some years ago where it might have made a substantial difference".
Gun control alone will not solve America's problem with violence but it can and has in the past made a substantial difference.
As it turned out, the national surveys used a different definition of the full SDM package, which made a substantial difference in SDM availability and use.
Because of an editing error, a misplaced quote of Wendy Sherman's made it unclear what Hillary Clinton's undersecretary of state for political affairs said might have made a "substantial difference" in Syria.
It was the largest economic infrastructure investment in the country since the second world war, and has made a substantial difference to the quality of life on South Tarawa.
So far, nothing has made a substantial difference in Casey's behavior.
In fact, here's a challenge: Can anybody think of a running mate who made a substantial difference?
