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Though the underlying mechanisms functionally linking ORMDL3 to asthma remain largely unknown, a growing body of evidence supports ORMDL3 as contributing to the etiology of asthma, where it likely participates in multiple pathways important to its underlying pathogenesis.
This supports the notion that age-dependent mitochondrial fragmentation is not a primary determinant of aging, even though it likely participates in the manifestation of some age-related symptoms such as sarcopenia.
Prolyl endopeptidase is also present in neutrophils where it likely participates in the generation of PGP. 3 PGP is broken down in the lung by the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H), an enzyme hitherto recognised only as proinflammatory through generation of leukotriene B4. 4 Consequently, acute PGP-driven neutrophilic inflammation may be terminated by LTA4H.
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MPV17 function is not well established but it most likely participates in mtDNA maintenance and metabolism of reactive oxygen species (Zwacka et al., 1994; Krick et al., 2008; Viscomi et al., 2009).
Furthermore, THC increases ROS production by the brain, which likely participates in its toxicity.
These findings imply that it is Hes1, but not Hes5 that most likely participates in the regulation of axonal growth, possibly via a Notch canonical pathway.
It produces solely GPP in in vitro assays after expression in Escherichia coli and likely participates in monoterpene biosynthesis accompanying induced oleoresin formation, based on dramatic increases in transcript level after methyl jasmonate application.
Loss of ABCA1, and other cholesterol transport proteins, accelerates lesion formation and likely participates in myeloid cell proliferation and function.
This isoform likely participates in local angiotensin II formation in both somatic and germinal tissues, and associates with certain physiological or pathophysiological events.
One group may have been retained during plant (or even eukaryote) evolution and thus likely participates in conserved, possibly essential processes, whereas another could have appeared more recently and likely participates in more species-specific events or is inactive.
Thus, Dot1L is upregulated by T3 and likely participates in the metamorphic transformations of different organs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com