Although it has been shown that Nutlin alone is very efficacious in MDM2 Ampl sarcoma cell lines in vitro and in vivo [ 11, 20], the effects of combinations with standard therapeutics in sarcomas is still unknown.
"Now, you must have a brake that is very efficacious and that the driver can dose, offering a very good sense of feel".
Goal-directed hemodynamic management is very efficacious early in the course of severe sepsis and septic shock [ 16], but ineffective if delayed [ 17].
In particular dealing with international, national and professional athletes", " I have a very good relationship with a [chiropractor]...given a diagnosis is established, his care is very efficacious!", and: " I go to one myself for neck and back problems".
As an alternative, ambisome, a liposomal formulation of amphotericin B, is very efficacious for visceral leishmaniasis, but this formulation is expensive and often out of economic reach for most of those who need treatment.
In a recent review of 344 dogs undergoing antiepileptic treatment of any kind in a referral clinic, only 14%% became seizure free [ 26], indicating that imepitoin is very efficacious in responsive patients.
Using this in vitro approach, we demonstrate that although the combination cisplatin-paclitaxel used at high doses is very efficacious in killing a large proportion of ovarian cancer cells encompassing broad genetic backgrounds, there are cells that escape the therapy and repopulate the culture following an otherwise apparent successful chemotherapeutic round.
The trial may be discontinued in either subgroup (RAS wild type and RAS mutated patients) when the treatment is very efficacious, but the trial may also be discontinued early in either subgroup if the new treatment is unlikely to show superiority to control based on the interim analysis.
Ondansetron was very efficacious on the first day of chemotherapy and its effect diminished over subsequent days.
The positive control adopted was Sam Allardyce, who despite being criticised by the estimable Johnny Giles for a lack of "humidity", has proven at this level to be very efficacious if not always immediately attractive – like removing a bunion with a belt-sander.
