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The essential contribution of NRP-1 to vascular development and neovascularization is also well documented [ 11] and, although its mechanisms of action remain incompletely understood, it is thought to regulate cell-surface-receptor clustering and signalling in a ligand-dependent manner.
It is thought to regulate cell morphology and adhesion through its connections to intracellular proteins and to extracellular ligands [ 12- 15].
The mechanistic role of gHgL in herpesvirus entry has been largely unresolved, but it is thought to regulate the activation of the virally-encoded gB protein, which acts as the primary fusogen.
Agrp is also expressed prominently in the adrenal gland [1], [21], where it is thought to regulate steroidogenesis [22].
G actin also shuttles into and out of the nucleus, where it is thought to regulate chromatin structure and transcription[12].
Far less understood, however, is a substantial population of STIM1that is able to bypass the ER retention machinery and traffic to the plasma membrane where it is thought to regulate Ca2+ entry through SOCs [3], [7], [30], [31].
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It is also a substrate for many protein kinases and is thought to regulate cellular contraction [ 7].
The nuclear lamina is thought to regulate gene expression by its direct interaction with chromatin.
The balance between these systems is thought to regulate growth of the eye during childhood.
The amygdala is thought to regulate this process, but in humans, acute stress and amygdala function have up to now only been studied in isolation.
m6A is thought to regulate RNA splicing, stability, translation, and secondary structure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com