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However, as described below, our further analysis of nDf59 revealed that it removed sel-11, a negative regulator of lin-12 activity, and it is therefore problematic to use nDf59 to draw inferences about mir-61/250 function.
It is therefore problematic to estimate the desired sample size.
It is therefore problematic to establish universal cut-off values across different sporting disciplines.
Most diagnostic labs have already invested in the optimization of PCR assays for the genomic regions of interest; it is therefore problematic to perform this optimization again in order to switch sequencing platforms.
It is therefore problematic to adopt a therapy in the ICU solely on the basis of its apparent effect on quality of life unless we know that this effect is not purchased by increasing mortality in the most debilitated.
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Distribution of relief assistance is, therefore, problematic and has to be mainly by costly air transport.
50 The wide variation in published estimates (1% to 50%) is therefore problematic.
Regarding such identifications as facts against which to test barcoding is therefore problematic.
However, as described in relation to Mao's coping question [ 35] above, improvement in coping is not necessarily correlated to improvements in pain and is therefore problematic.
10 Intimate partner violence is therefore problematic when traditional screening criteria are applied 11 because it is a complex social phenomenon rather than a disease.
Defining life, as with defining species, is therefore problematic.
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