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The conserved histidine residue in sensor kinases is the site of autophosphorylation [19], [47], where it is suggested to function as the nucleophile that attacks the ATP γ-phosphate [48], [49].
The protein is expressed in the skin but also the CNS [ 131, 132] where it is suggested to function as a corepressor for multiple nuclear receptors [ 133- 135] including the thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptor [ 136].
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Interestingly, a gene called MATERNAL EFFECT EMBRYO ARREST 25 (MEE25) coding for a UDP-glucose 4-epimerase was also in this group and it was suggested to function in male reproductive development [ 42].
A strictly conserved glutamate residue is suggested to function catalytically in thioester proteins.
Akt is suggested to function as a G2/M initiator.
It has been suggested to function in linking membrane to membrane and membrane to cytoskeleton [ 33].
As YKL-40 contains HLA-DR4 binding motifs, it has been suggested to function as an auto antigen in RA [ 11- 15].
It has also been suggested to function as an E3 ligase, and is itself regulated by ubiquitin-dependent degradation mediated by E2 UbcH5 and E3 Nrdp1 (Qiu and Goldberg, 2005).
Rab27B has been suggested to function as an oncogene in breast cancer [ 32] because it is responsible for regulating many secretory mechanisms [ 15].
This pathway was suggested to function in parallel to Notch, and to allow modulation of dendrite growth by soluble factors even in the absence of cell-contact signals.
AQP1 has been suggested to function as an ion channel upon cGMP activation, although this idea has been controversial.
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