It has been demonstrated that axonal microtubules show increased stability; when a caged form of taxol is used to stabilize one neurite, it was sufficient to transform it into an axon (Witte et al. 2008).
Expression of M3-protein on its surface is sufficient to transform the S. gordonii strain into a bacterium with a high binding capacity for CIV and CB3.
SRSF1 (previously called SF2/ASF; Manley and Krainer, 2010) is upregulated in various human cancers and its overexpression is sufficient to transform rodent fibroblasts and cause high-grade sarcomas in nude mice (Karni et al, 2007).
For the oncogenic Kit-D816V mutant identified in patients with systemic mastocytosis and corresponding to the GIST PDGFRα-D842V mutant, it was previously reported that its localisation to the ER/Golgi compartment is sufficient to transform cells to cytokine independence and to induce diseases in mice [ 22].
It has also been reported that overexpression of SERTAD2 is sufficient to transform murine fibroblasts and promotes tumorigenesis in athymic nude mice due to the deregulation of the E2F/DP-transcriptional pathway thanks to the upregulation of the key E2F-responsive genes [474].
In contrast to the transformation of HMEC-DD cells, one oncogenic event is sufficient to transform Rat1-DD cells, indicated by both anchorage-independent growth in vitro and tumor formation in vivo (Ni et al., 2012).
In contrast to the transformation of HMEC-DD cells, one oncogenic event is sufficient to transform Rat1 rodent fibroblasts expressing p53DD (Rat1-DD) cells, as indicated by both anchorage-independent growth in vitro and tumor formation in vivo (Ni et al., 2012).
Furthermore, overexpression of wild-type NSD2 is sufficient to transform NSD2-/ cancer cells in vivo and in mouse embryonic fibroblasts (MEFs) (Kuo et al., 2011).
Whether the use of a gmail account instead of one's official dot-gov account is sufficient to transform otherwise public records -- records that belong to the people -- into the personal property of government officials, will be decided soon by the Third District Court of Appeal.
No study so far addressed the question whether acquisition of a polybasic cleavage site is sufficient to transform a LPAIV H5 precursor into a highly pathogenic H5 virus.
