Direct assays of oxidant induced cell death indicate that most 'free' iron is concentrated in lysosomes [ 1574- 1577], that its decompartmentation is substantially involved [ 1570], and that its chelation can thus prevent cell death [ 1578 - 1581]
for which the Secretary determines that a local government is substantially involved in the development of the project.
Taken together, these results indicate that Rho-kinase is substantially involved in the myocardial remodeling after TAC and MI associated with upregulation of profibrotic gene expression and TGF-β1 TAK1 paTGF-β1 TAK1her suggest the pathwayive efurtherf fasuggestn hearthegainst protectiveal stimuli by inhibiting reffecte fibrofis.
Among the above mechanisms, we assume that the medulla is substantially involved as a hub structure related to interictal WPH, because similar brainstem volume reduction and structural alteration [75, 76] were observed in migraine and FM, and it includes the serotonergic system from the rostral ventromedial medulla, which has been implicated in migraine and FM pathophysiology [80].
Recent studies of functional and effective brain connectivity in nonimpaired readers suggest that the left OT cortex is substantially involved in driving brain activation in left inferior frontal areas (e.g., [51] [54]).
Recent data in mice as well as in humans demonstrate that PD-1 is substantially involved in the control of T-cell homeostasis under physiological and pathological conditions [26] by preventing uncontrolled proliferation of autoreactive T-cells [27].
Moreover, ROCK is substantially involved in the pathogenesis of coronary vasospasm, angina pectoris, hypertension, pulmonary hypertension, and heart failure [ 38].
"Even if a utility prudently managed its infrastructure at the time of a fire, the utility could be held accountable for damages if its infrastructure was substantially involved in causing the fire, potentially exposing the state's utilities to significant liabilities," Moody's analysts wrote.
Although the role of eotaxin in diabetes is still being elucidates, it is thought to be substantially involved in the development of the disease in patients with type 1 diabetes [ 43].
But this discards a vast amount of data – any areas of the brain that show weak activation aren't considered for further analysis, as they're assumed to not be substantially involved in whatever it is that you're measuring.
DJ made substantial contributions to the conception and design of this study and was substantially involved in the acquisition, analysis and interpretation of data.
