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It is solidly established that the enzyme cleaves proteins and peptides on the carboxyl side of lysine and arginine residues employing a well-understood specific binding mechanism that recognizes the basic side chains of those amino acids.
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Darwinian evolution has long since passed that test and is solidly established as the foundation of modern biology.
It is critically important to emphasize that our data do not negate a tumor suppressor role for ATM, which is solidly established both in human and mice (see Introduction), but question the generality of the model proposed for ATM as a critical mediator of p53-activation and senescence in response to oncogenic signaling [17], [18].
The investment case for education and healthcare services for children is solidly established.
The basic facts of human evolutionary history are solidly established, but this doesn't mean that there aren't a lot of interesting open questions and many significant fossils waiting to be found in coming years.
Others, less widely renowned, are solidly established: Susan Rothenberg, Elizabeth Murray, Terry Winters, Carroll Dunham.
The sense/antisense ancestry of the aaRS appears to be solidly established.
One doctor pointed out that routines and working methods for the handling of drugs are so solidly established that it is easy to forget alternative treatments.
It is solidly confirmed that RNPC1 play pivotal roles in regulating wide biological processes, ranging from cell proliferation, cell cycle arrest to cell myogenic differentiation [ 13, 18].
The main consideration is that the switch must be mounted so that nothing interferes with its operation and that it is solidly mounted.
Especially now that it is solidly differentiating its approach from the rest of the pack.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com