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It is sobering for all London nationals to reflect on the proliferation of big non-political domestic stories in and around the north this year, such as Dale Cregan, April Jones, Chetham's music school abuse, plus the Jimmy Savile scandal.
Yet it is sobering for me — as it is for Americans in many businesses and professions that once seemed a sure thing — to see younger near contemporaries being downsized out of jobs long before they are emotionally or financially ready for retirement.
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It's sobering for those on the left to realise that the first politician to commit to their abolition was Enoch Powell.
"There is so much hope invested in stem cells that it's sobering for all of us to realize what a long time it takes to bring a safe and effective therapeutic into widespread clinical use," Dr. Hall said.
It's sobering for me to reflect on the reality that women like me, with my life experiences, will, in all likelihood, no longer exist in two generations.
It was sobering for us to see this shantytown up close, especially as we saw groups of school-aged children along the road who clearly weren't in school.
The result is sobering for opponents.
The McGwire comparison is sobering for the Angels.
That is sobering for anybody tempted to chop down rainforest and plant something more immediately lucrative.
(It is sobering to realize that but for John Law, folks would be speaking French in Little Rock).
It is sobering to consider that, in 1971, for women in their twenties, there were 154.5 live births per 1,000 women.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com