When the decision to implement the delirium prevention protocol was taken, it was prospectively decided to evaluate its effects after one year.
It was prospectively registered at the Australian New Zealand Clinical Trials Registry (ACTRN12614001168640).
Preoperative, intraoperative, and follow-up information was available for all patients, and it was prospectively collected and retrospectively reviewed.
It was prospectively designed that animals developing the consecutive stages of HF (mild, moderate, and severe) during the experiment would be presented for euthanasia.
Once the 21-gene RT-PCR assay was defined it was prospectively validated using a cohort from the National Surgical Adjuvant Breast and Bowel Project (NSABP) trial B-14 [ 22].
In contrast, because it was prospectively identified, crizotinib was recently approved by the US Food and Drug Administration FDAA) only for the treatment of advanced NSCLC proven to harbour an ALK gene rearrangement, an abnormality present in <5% of the NSCLC population (Kwak et al, 2010).
In order to ensure that the widest possible range of items were considered in the third stage of the reporting guideline development process, it was prospectively planned that all items identified within the systematic review would be included for comment in the Delphi process.
First, a cross-sectional observation is exploratory in nature, and it should be prospectively replicated.
30 It has been prospectively registered with the Australian and New Zealand Clinical Trials Registry (365331).
However, our study was performed on mRNA, so it should be prospectively supplemented with research on functionality of the protein products of these genes to assure the association of expression, mitochondrial potential, and apoptosis with imatinib resistance.
