Throughout the nineteen-nineties and early two-thousands, it was prohibitively difficult for an independent game maker to reach a wide audience.
That's the defining difference between the US and British systems: in America, it's prohibitively difficult to overturn a supreme court decision.
Synaptic integrity is a strong indicator of cognitive health in the human brain;however, until recently, it was prohibitively difficult to perform detailed analyses of synaptic and axonalstructure in human tissue sections.
Argentina and Venezuela are approaching crisis conditions, and immigration to the United States is prohibitively difficult.
For some time now, synthetic biologists have recognized that rational design – creating entire bacterial genomes from scratch – is prohibitively difficult because of the vast complexity of living systems, of which we have only limited knowledge.
Despite optimality of centralized techniques in resource allocation, finding the analytic formulation and in turn the optimum point is prohibitively difficult due to the non-convexity of the associated optimization problem [16, 17].
Since the task is prohibitively difficult for a gene that is found in just one genome, a practical modification of the problem is to label each set of orthologous genes, shared by several genomes, as either ancestral or non-ancestral (see [ 5] for definition of orthology and discussion of issues in practical detection of orthologs).
That may sound reasonable, but it can be prohibitively difficult, said Helena Peacock, the legal director of Penguin Books in Britain.
Hastedt, whose group provides legal aid to low-income Mainers, said it can be prohibitively difficult for people with health problems, limited access to transportation, and other barriers to prove that they qualify for an exemption.
