This work identified a compound 53 with very good in vitro/in vivo efficacies, good DMPK properties together with better hERG tolerability and it is currently being profiled for the evaluation as a potential pre-clinical candidate.
"To me, it was obvious we were being profiled for being black twice," Abdur-Rashid tells VICE.
It's the way people are reduced to sets of high-priority characteristics — it's profiling, for tracking, targeting, and marketing.
Groupon has been profiled for its distinctive writing style.
For Roosevelt it was a New Deal, for Kennedy it was Profiles in Courage and support for civil rights, and for Johnson it was a Great Society, a War on Poverty and economic opportunity.
A silhouette of a shapely woman was profiled and underneath it said, "For truckers, Winslow, Arizona".
Of all the profiles offered by the H.264/AVC JM Reference Software, we selected the "extended profile" encoder, because it is a profile for efficient video streaming.
Finally, for the specific case of the NCI-60 cancer cell line dataset, since it has been deeply profiled for many types of research (drug response, chromosomal aberrations, mutational status, etc).
SH2 profiling is highly sensitive and throughput is relatively high, thus it is ideal for profiling phosphotyrosine (pTyr) signaling in cancer cells.
It is important to profile surviving patients for effective planning and evaluation of ongoing care.
Because of this it is not the ideal choice for miRNA discovery but it is useful for profiling conserved miRNAs.
