While it is problematic to assign ancestral versus derived states to gene duplicates originating from WGD events, we reasoned that a paralog within an ohnolog pair could be characterized as being ancestral-like or derived-like based on the extent of gene-neighborhood conservation it shared with a single-copy ortholog in an outgroup genome.
You don't have to agree with that proposition to acknowledge that it might be problematic for state governors of either party to have their potential advantages of executive experience, pragmatic deal-making, and budgetary responsibility become an electoral liability.
Prescribing drugs without adequate indication is problematic, as stated by an interviewee: "Herceptin is supposed to be used only by those patients who are receptor positive.
This flaw is problematic in a state where the gender gap has been hugely important and women are the focus of constant campaign communication.
He is sympathetic to the fact that, naturally, people become involved when an issue affects them, but also sees how it can be problematic, stating: "When there was an issue with local tennis courts, some more affluent residents might turn up and campaign.
It can certainly be argued that the choice of 16-state models is problematic because it is difficult to fit these models to real data due to their parameter richness and heavy computational costs.
"Engaging Iran is problematic, especially given the state of the US-Iranian relationship.
The fact that a source hasn't been identified to come up with the $515 million needed to pay off Detroit's debt also is problematic, although a $250-million 250-millionom transfere's general from has been included theestateish the new district.... Duggan didn's support or reject the legeneralon.
There appeared to be a prevailing sense that this was a difficult area in mental capacity determination and in particular that separating the normal emotional response to life limiting illness and an abnormal mental state is problematic.
Since the reconstruction of ancestral states for sites with gaps is problematic, we restricted the analysis to only sites with no indel in any species.
