Placebo-controlled trials using chemowafers, which have proven efficacy in high-grade gliomas, 20, 22 are problematic to design for single and oligometastatic brain cancer, for which there are multiple existing options (eg, surgery alone, SRS alone, resection plus SRS, resection plus WBRT) and deeply held biases.
The results suggest that even with carefully designed tasks, it is problematic to directly compare scores from initial tests and retests.
One of the reasons for using Euclidean and/or Manhattan distance is the relative ease of their implementation; in contrast, it is more problematic to design algorithms implementing actual road network distance in spatial analytical models.
The high PM level on the day of the storm is problematic to model, the indicator variable is designed to capture the extreme PM levels occurring on the day of the storm and after-effects.
On close inspection, it seems to be problematic to remove all coloring, since perfect filter design is hardly achievable, which makes employing an exact inverse of the receive filter seem impossible.
It is problematic at the early stage of structural design.
This factor is likely to be problematic to small household or community anaerobic digester designs that cite methane production as a key driver for gaining energy neutral systems or for additional cost recovery.
This loading on working memory is problematic for studies designed to investigate the preservation of online syntactic processing in relation to neural changes across the life span because working memory is itself known to decline with age (Just and Carpenter 1992; Braver and West 2008).
Our findings support the view that conceptualising men as a homogenous group is problematic when designing health improvement interventions [ 22, 48].
The lack of post Food and Drug Administration (FDA -approval acceptance studies among males aged 18–26 years is problematic relative to the design oFDA -approvallomacceptanceV) vaccine promotion programstudiesned to tamong males.
