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Although FXIIIA is best known for its role in blood coagulation, where it is present as a pro-enzyme dimer bound to dimeric inhibitory FXIIIB subunits (A2B2) and where it stabilizes fibrin clots after thrombin activation [50], [51], growing evidence points to additional cellular roles.
It is present as a mid-level repeated element in its host insect genome (about 50 copies/genome) [ 19, 24], it encodes a set of proteins (gag, pol, env) with features similar to those of well-characterized retrovirus proteins [ 17] and it is capable of producing virus-like particles [ 25].
In other words, can one say that a jar is absent as a cloth even in a locus in which it is present as a jar?
The advantage of the resin over hydrochloric acid as a catalyst in these reactions is that it is present as a separate phase that does not contaminate the product.
However, it is present as a single copy in the cell surface HA-binding receptor, CD44, and in TSG, a secreted matrix protein whose synthesis is induced by inflammatory cytokines.
DLS and AUC experiments indicated that the ETD-like is monomeric in solution whereas it is present as a dimer in the asymmetric unit indicating that oligomerization is not related to functional differentiation among these toxins.
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