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Paradigmatic studies in Dr. Bissell's laboratory have shown that it is possible to revert the malignant phenotype by targeting environmental factors [24], [26], [27] and by correcting alterations in signal transduction pathways [28], [29], both in vivo and in culture, without altering the genetic lesions of the tumor, summarized in [30], [31].
Specifically, Beauséjour et al (2003) have shown that it is possible to revert cellular senescence following inactivation of p53, if p16 is concomitantly down-regulated.
We show here that it is possible to revert the tumor phenotype of the RD cell line by silencing EZH2 even under proliferative stimuli such as in a serum-enriched molecular context.
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DOI: http://dx.doi.org/10.7554/eLife.02304.015 Alternatively, it may be possible to revert a modern apicomplexan LDH to MDH-like specificity by deleting its six-residue loop insertion.
Therefore, it should be possible to revert the decrease in sIPSCs observed in the Rac1N neurons by adding an antagonist for the CB1Rs, to prevent the inhibition of GABA release from CB1R-positive inhibitory terminals (Lee et al. 2010).
Any breach of confidentiality may not be capable of remedy or reparation as it might not be possible to revert to the 'status quo ante' following disclosure of the confidential information".
Chromatin-mediated repressive effects on gene transcription are usually ascribed to DNA methylation or histone deacetylation and several studies have shown that it is possible to pharmacologically revert some of these effects (40,41).
Thus it is possible to trace changes and possibly revert to a previous state if needed, but more importantly to comprehend the annotation history of every gene and annotation version.
Our results therefore prove that it is possible to completely convert an embryonic somatic cell genome into a state of fetal liver hematopoietic progenitors without having to first revert to an embryonic state.
"It is possible to intensify.
However, while it is possible to temporally down-regulate the Th1 response by passively blocking Th1-type cytokines or by administering Th2-type cytokines, the response reverts back to a Th1 response once treatment is stopped [23].
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