Concerning a possible mechanism by which PC influences the expression of TRAIL and its receptor, it is possible to hypothesize that the two transcriptional factors NFκB and HIF, involved in PC neuroprotection, may have a fundamental role.
Due to the unusual structure and catalytic motif of TaPDIL8-1 is is difficult to predict its functional role, whereas it is possible to hypothesize that TaPDIL3-1 could retain at least partially its original function.
In light of such data it is possible to hypothesize that NF- κB exerts its antiapoptotic effect through the induction of miR-21 which in turn negatively regulates the expression levels of cell death inducer PDCD4, thus leading to a protective response during cytokines exposure of beta-cells.
If this is the case, then it is possible to hypothesize that conditions, such as infectious disease, that increase systemic inflammatory burden should also increase the risk of PE.
In light of considerable advances in molecular and radiobiological characterisation of GBM, it is possible to hypothesize that certain subsets might be more responsive to the effects of radiotherapy, and trials enriched with such patients might in fact provide a basis for testing a possible survival advantage with higher doses of radiotherapy.
Based on direct observations of each boulder (size, shape, weight and long axis azimuth), together with hydrodynamic equations it is possible to hypothesize the extreme event geodynamic or meteorological— which was responsible for this singular accumulation.
It is possible to hypothesize that some proteins should be more sensitive to the free radicals derived from the same system.
For instance, it is possible to hypothesize that absence of a nuclear expression of KLF6 prevents the regulation of specific target genes involved in negative control of cell growth.
In this scenario, it is possible to hypothesize that ET-1 through ETBR can stimulate angiogenesis and lymphangiogenesis via HIF-1α providing an alternative or complementary mechanism to the tumor hypoxic microenvironment.
If the native configuration represents the more favorable energy state for a protein in accordance with Anfinsen's thermodynamic hypothesis [18],[19], then it is possible to hypothesize that the thermodynamically most stable native state must represent the more favorable antioxidant state and the driving force that moves the protein thiol groups towards the most favorable location.
Therefore, it is possible to hypothesize that the tendon length decreases from arboreal to terrestrial primates.
