However, since myogenic signalling is perpetually active, the canonical mechanism of proteolytic shedding of TNF would rapidly deplete the constitutive TNF resources and is, therefore, intuitively unsustainable.
Of the options available, an mTNF signal makes intuitive sense: since myogenic signalling is perpetually active, proteolytic shedding (that cleaves mTNF to release sTNF) would rapidly deplete cellular TNF and is, therefore, unsustainable.
If we were perpetually active, we would also be perpetually needing food, so the evolutionary strategy would be too inefficient – running around consuming as much as possible so that we can carry on running around.
Like all other projects, it is perpetually in progress.
It is perpetually referred to in guide books and travel stories as "like Thailand 10 years ago".
For the world's ecosystems, seagrass is valuable, but it is perpetually threatened by pollution and climate change.
It is perpetually dinnertime at the airport, but I do not want the food.
The mountain or ocean may appear unchanging, but it is perpetually in flux.
It is perpetually provoked, it is historically-bound, and, thus, it is bone-deep.
It's perpetually Easter, with bunny representations everywhere.
Someone in that office is perpetually "looking into it".
