It is particularly difficult to treat because of its remote location, late presentation and resistance to conventional chemotherapy.
Unfractioned heparin is a mainstay drug used in the hospital setting; yet, it is particularly difficult to dose due to its unpredictable pharmacokinetics.
It is particularly difficult now, when the overall economy is weak.
"At the moment, it is particularly difficult to get information from developers on progress".
It is particularly difficult to show true trans-generational inheritance in humans.
It is particularly difficult for non-Americans to get such clearances.
Because salt and fat both affect moisture, it is particularly difficult to make a product that is low in both.
For Giants fans upstate, though, it is particularly difficult to think about a summer without training camp.
And it is particularly difficult to pin down the United Nations' role in managing economic globalization and development.
Chasing 324 would be hard enough at the best of times, but under lights it is particularly difficult.
It is particularly difficult to answer among groups like the Bangladeshis, who resist assimilation and interracial mixing.
