It is noteworthy to consider that in this study we have examined only the expression of FcγRIIb, but not its function, which if altered could also affect the regulatory ability over the humoral response against citrullinated proteins.
With regard to costs projected in our study, it is noteworthy to consider that compared to the SHEP treatments, costs of treatments based on more recently developed antihypertensive agents (than reported here) are likely to be even higher than estimated in the present analyses.
It is noteworthy to evoke the study of Naugle et al. [ 47] on mixed anaerobic cultures which demonstrated that a rise of the environmental pH from 7 to 7.5 induces a marked proliferation of P. gingivalis, from numbers less than 1% of the entire microbial community to reaching predominance of that culture.
It is noteworthy to mention that the study of Bopp and colleagues [ 7] was a pilot study that included only five patients.
It is noteworthy to mention that this study was initiated before the release of Norway and white spruce genome sequences [ 53, 25].
As our study included a portion of the samples of the previous reported study it is noteworthy to mention that the results of the current study excluding the previously analyzed samples show the same protective effect and borderline significance (GG+GC versus CC ORR = 0.37, 95%CI = 0.13-1.08, p = 0.059).
It is noteworthy to mention that a previous study found that human skeletal muscle cytosol completely lacks Apaf-1 and therefore is refractory to cytochrome c-mediated caspase activation [21].
However, it is noteworthy to mention that in these studies neither the nonlinear relationship between the variables nor the effect of gasoline prices (which is the main source of inflation) was analyzed.
Hence, it is noteworthy to point out that several studies have shown benefit from short-term glucose-lowering interventions on CVD risk factors, surrogate markers of CVD (18, 19), as well as absolute CVD event rates (20) in people with prediabetes.
In accordance with a previous study, it is noteworthy to mention the occurrence of a Xanthomonadaceae family member associated with immature eggs that may be vertically transmitted from the mother to the offspring [ 51].
