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It was not possible to undertake a sensitivity analysis since none of the studies included in the meta-analysis were randomised controlled trials.
Unfortunately, it was not possible to undertake measurements of SOX9 protein in our patient sample.
In addition, it was not possible to undertake histology review.
As 3 only forms gels in toluene, it was not possible to undertake studies on this compound.
Due to the limited number of comparisons available, it was not possible to undertake any subgroup analyses or sensitivity analyses.
It was not possible to undertake all procedures with some of the cartilage samples that did not yield at least 1 μg total RNA.
We performed a descriptive analysis as it was not possible to undertake a meta-analysis due to the heterogeneity of the interventions.
However, because of the absence of good quality data on the factors often hypothesized to influence inefficiency it was not possible to undertake the analysis.
Due to the range of outcome measures and data collection methodologies it was not possible to undertake a meta-analysis or funnel plots.
Unfortunately while it is not possible to validate all RNAseq findings, we have however undertaken the task of doing so for some germline and proliferation genes.
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