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We show here that PrPC is localized both in coated and in smooth areas of the plasma membrane (Figure 4) and in line with other evidence [73], it is internalized in late endosomal/lysosomal structures (Figure 4 d e) with a peak of internalization after ∼30 minutes (Figure 1).
We further characterized the fate of HIV-1 after it is internalized in renal epithelial cells.Primary or immortalized CD4 cells were infected with a green fluorescent protein (GFP -expressing replication competent HIV-1.
Our model is agnostic about the extent to which liability for reversal risk should reside in private or public hands, as long as it is internalized in some way.
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It is important that DRR is internalized in SME businesses.
For SARS-CoV, it is proposed that the virus is internalized in the cell by endocytosis, and is then exposed to a low pH environment, and it is postulated that proteolytic cleavage between the S1 and S2 domains initiates the membrane fusion process [16].
In addition, since the liver has been identified as the organ receiving the higher dose, owing to its high uptake [4, 62, 63], it is important to understand whether 64Cu is internalized in the nucleus of hepatic cells or not.
For instance, 90% of cholesterol is present at the cell surface in normal cells and it has been observed that majority of the cholesterol is internalized in Presenilin double knockout (PSENdKO) cell lines [15].
These results suggest that Bin is internalized in association with its receptor but is not targeted by the vacuolating autolysosomal compartment.
We found that CysLT1 is internalized in a clathrin/Rab-5-dependent pathway; we also suggest that this internalization is arrestin-3-dependent.
His 1952 book, "Black Skin, White Masks," offers a penetrating analysis of racism and of the ways in which it is internalized by its victims.
FRα is internalized in a caveolar structure as early endosome19.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com